Will first OPT deniel cause problem for 2nd OPT?

Hello Everyone,I have few questions on OPT. Recently my initial opt denied,As i already completed grace period i reentered from mexico with new i20 and sevis. 1.Can i apply Opt after completing second masters?2.Will different sevis number on visa be a problem if i apply opt?3.Will first OPT deniel cause problem?Can anyone please answer my questionsThanks in advance.