What to do if passport re-issued after submitting DS-160 and booking H1B stamping appointment

I’ve never got my passport stamped with H1-B. Now, I’ve to get my passport re-issued. With my original passport, I submitted DS-160 and booked an appointment for H1-B stamping in India. The CGI federal website doesn’t give any option to change the passport number for my profile. Can I still go ahead with my original passport number and the current appointment or should I submit a new DS-160 and create a new account?

Just submit a new DS-160 with updated passport information.

Thanks for responding! Does that mean, I should still be able to go ahead with the current cgi federal account and appointment and I just have to update DS-160 Confirmation Number in the profile.

Your understanding is correct.

Yes. You can also talk to the VFS helpdesk in case of any concerns.

https://www.ustraveldocs.com/in/en/contact-us