In person interview

During my last visit in 2014, i got 221G and my visa is stamped with clearance received. I have in person appointment scheduled in June @ chennai for Visa stamping. Will there any issues? Is there a chance i will be getting 221G again?

Not necessarily and not just becuase you got 221g last time. Each visa application is accessed independently and based on the fact and supporting documents. Of course there could be several other reasons that you may get a 221g.