H4 to H1B. Consequences of travelling to India before Oct, 2015.

A Consultancy Firm is filing H1B for my wife. So, the application will be filed on 1st April, 2015.

If everything goes well and her application is accepted, can she travel to India in June, 2015 without hurting her chances of getting the H1B visa?

What is the best possible way out to travel to India in June, 2015 and be back by Aug end? Any specific things to be taken care of?

Yes. She can travel and there is no problem.