Can I apply for H4EAD while H1B and my H4 extension still pending?

Hello All,
My H4 EAD will be expiring in few weeks and my spouse H1B and my H4 extension is still pending. I have both H1B and H4 receipt notice. Can I apply H4 EAD with this H1B receipt notice? If yes, should I send I-765 application to the centre where my H4 extension is filed or to the centre based on the first 3 letter of my receipt number?