carrer option after in ms in it

I have Done my here in India.
I already applied for us 3 times To Pursue MBA IN GERNERAL.
Now I am planning to apply direct h1b visa or work.
As my relatives live their and
One of my relative is having their own motel
And second relative is having their own store.

And yes I am also planning to get admission in master of science in information technology.

So now My question is
When I should apply for visa after master or right now…??

Or My relative can put file for me to get direct visa as they need my help or something…

I am waiting for your answer…