Applying H1B visa: DS-160 QUSTION: Have you ever been refused a U.S. Visa

In 2010 I applied for B1/B2. It got rejected. I applied second time in a month time - which got approved.Now (2015), I am going to apply for H1B, in DS-160 it asks for any instance of visa refusal.The question is as below:

Have you ever been refused a U.S. Visa, or been refused admission to the United States, or withdrawn your application for admission at the port of entry?

Can I say No? as it got approved in second attempt.OrYes and mention about refusal in first attempt and approval in second attempt?Thank you.

Answer yes. It should not be asked about during the interview, but even if it is you can mention what ever happened. They would anyway know about it even if you tell them no.